The 'conventional' wisdom is 'yes and no'. 120 film has a paper backing all the way along, 220 only on the start and end of the film. So to get the same lens-to-film distance, the 220 back has a pressure plate that is a little further forward than a 120 back to take account of the film thickness. The power backs that can take 220 and 120 film have a moveable pressure plate that takes this into account. So technically if you put 120 film into a 220 back, the surface of the film would be closer to the lens due to the backing paper and you might then get a focussing error. I have never tried this myself, so I have no idea what the actual effect would be, though I imagine it would be small. You also have to remember to stop shooting once you reach 10....