I scan 4x5 on a V750 at 2400 ppi with no issues using Epsonscan. I use a sheet of anti-newton ring glass with the dull side down spaced over the platen at the optimum height using rubber feet. I tape the negative to the underside, emulsion side against the glass; i.e. up, and put a cardboard 4x5 window mask over the whole thing to reduce glare at the edges of the scan. It works well enough.
In the worst case, even if the scanner can't handle an entire 8x10 neg at that resolution, you could scan it in sections and stitch them in photoshop.
Go to a glass place and get two sheets of anti-glare picture frame glass. Get them sized to fit within the glass area of the scanner. Put one sheet down on the scanner glass with the anti-glare side up. Add the negative, then put the second on top with the anti-glare side down. In other words, put the anit-glare sides against the negative to eliminate Newton rings. Put the Epson negative mask down first. The bottom sheet of glass raises the negative so that it's in focus.
I've been doing it this way for a dozen years.
I believe that for the V7xx and V8xx, when the 8x10 transparency mode is selected, the scanner expects the original to be flat on the glass. That is why there is just an 8x10 "area guide", and not an elevated film holder like there is for all the other formats.
Doesn't putting anti glare glass under the neg blur the fine detail?
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