The exposure difference may be "insignificant", but it' s worth setting your meter to the correct speed. With very warm light (say, lighting diffused through unbleached muslin), the speed is very probably even lower. Maybe it's even a touch higher when exposing under pure skylight, who knows.
The old black and white stocks, such as 5222, have had little or no R&D in decades, so it's effectively a vintage stock, and the latitude can't even remotely compare to a contemporary stock like the Vision3 series or with the Alexa digital system. I found that I had to be very careful with exposing and lighting 5222 and 5231 or it fell apart quickly.
Actually, you can easily and significantly alter the shutter speed in cinematography, in both analog and even more so digital capture. The standard is a rotating shutter, where the maximum opening is 180 degrees (or 210 degrees with a Panaflex), which provides a 1/48 shutter speed at 24fps. Depending on the camera, it can be narrowed down in frequent increments to as much as 11 degrees, which by my late-night calculation is 1/768th of a second. however, audiences are visually accustomed to the 1/48th look and so anything outside of that is considered a special "look." The battle scenes in Saving Private Ryan are the most famous example of this (between 22.5 and 90 degree shutter), although it was an action scene trend well into the 2000s.
Thus, ND filters are used widely to most accurately control exposure when you want consistency of stop/depth of field/sharpness throughout a film. Many lenses, very especially older ones can become totally different lenses at different stops, as you know. During partially cloudy days, the dance of ND filters can be maddening, but my method is to choose an f-stop for a film and never stray more than a 1/2 stop in either direction for said consistency. All apertures in my last film were between 2 3/4 and 2.8 3/4 for example. Exceptions were certain less-narrative landscape shots where soft foreground elements might be distracting and working with real candlelight where I had a few high speed lenses on hand but even then softness becomes objectionable to my eye below 1.4 3/4 with a "vintage" lens.
Cinematography can be exposed very precisely, between the widespread use of lighting and the use of T-stops instead of F-stops. It's kind of funny that people try to exercise such precise exposure control in zone system photography, when they don't know the actual transmission of the lens, just the crude size of the aperture opening. This additional level of precision is required in cinematography because of the directly viewed shot-to shot consistency required and also the large viewing size of the finished image where differences in shadow detail and noise are greatly exaggerated. That said, the current recording materials have an uncanny level of latitude and newer generations of cinematographers by and large do not exercise the same level of technical craft as their predecessors.
J