You can shoot short rolls and/or multiple bodies, as long as you have tested to make sure the shutters are all in calibration with each other, or established a working EI using each body/lens.
Barring that, you can just find your working EIs, normal development, and pluses and minuses, place your shadows, and take notes for what to do in development as if you had the luxury of being able to do it for each shot. Then, when you are looking over your notes for each shot on the roll, you can figure out what sort of development would be the best compromise for all the shots on the roll, or pick certain shots to favor when you go to develop.
In the basic zone system manual, which is one short chapter of the Ansel Adams book "The Negative" plus some info in the appendix, I believe he wrote that he usually developed a roll of film shot in mixed contrast to N-1, as it usually provides workable negs even if the contraction was not needed on some shots. It is easier to deal with a neg that is well exposed, yet still a grade or two too flat than it is to deal with a neg that is a grade or two too contrasty. This also reduces the appearance of grain, which is more important in smaller formats. Some people using roll film prefer to selenium tone to get to their desired expansion, as it does not increase grain.
Personally, with 35mm, when using a spot meter (not usually, but I do do it when I have the time), I use the best compromise for the whole roll. If there are going to be extremely different development instructions for the first vs. the last half of the roll, I will rewind one roll but leave the leader sticking out, mark how many shots have been exposed, and load a new roll. Then I can either just eat my losses and develop the partial roll, or reload it, stop all the way down, pick the top shutter speed, cover the lens, shoot through the number of already-exposed frames, insert a few frames afterward for safety, then finish the roll. Another option is to reload the film into the camera in the darkroom, shoot through the number of exposed frames, shoot a few safety frames, then open the camera (in complete darkness, of course), cut of the exposed film, and develop it. You are left with a partial roll that you can shoot later.