Sure, sharpness should not be a problem but color temp and color tone - especially using color negatives, will be a challenge.
Of course when using color negatives and b&w one film characteristic that will be very challenging to emulate with any digi will be the near infinite overexposure. Below you can see that even in RAW with post work they are completely blown out unrecoverable past +4 while Portra 400 goes well beyond. You can see that with the mildest of post work on the +10 frame, one can reasonably recover it even using white balance and levels. Obviously I didn't shoot enough frames to see where it actually ends as I didn't expect going +10!
What can you do with this info? Well let's say you encounter a scene that your camera's meter is recommending 1/60 and you need 1 second well you will have confidence knowing you will have something you can work with. This is what I did with this scene taken with Kokak Ektar 100 as I needed to smooth out the waterflow.
And while I'm on long exposure, clearly that is one aspect of film photography that can only be done with a film camera.
This one taken on Kodak Ektar 100 using aperture priority mode on my Pentax LX - the only camera ever that can do this, and the autoexposure was more than 40 minutes.
Anyway, good luck on your interesting project as you will have many things to work out. Maybe you'll find just shooting film to be the better option . . .