Hmmm. I've had that same trouble no matter what I've tried and scanning is still generally a mystery to me. This time, I scanned at pretty high resolution (24bit, 6400dpi) and the lowest compression jpeg came out to 24MB (13290x13461). Cropped in PS Elements and saved as tiff, came back later to do the dust. For posting, did "save for web" at 1000 pixels on the longer side (that's still the Photrio limit, isn't it?) and chose lowest jpeg compression. Comparing with the original tiff, this is still sharp but has considerably less detail in all the delicate parts.