The difference between a process lens and a purpose designed enlarging lens is the magnification ratio for which the optics are optimized. As stated above, process lenses are optimized for 1:1 reproduction. Depending on the focal length, (relative to film format), enlarging lenses are generally optimized for magnification ratios 1:2 or greater. The smaller the focal length, the greater the ratio required. Logically, it makes sense that an 80mm for 6x6 would be optimized closer to a ratio around 1:5, whereas a 300mm would be optimized for a ratio around 1:3 and a 360mm at 1:2. So the longer the focal length, the less the magnification ration deviates between the 2 types.
All of that aside, I use a 300mm Apo-Ronar for 8x10 work. It works great! It is sharp and contrasty. But if you are used to working with purpose built enlarging lenses, the lack of click stops and the orientation of the f-stop lettering is a user interface challenge.
Cheers,
Geary