I have all my primes in one big Trekker bag.
I have all my zooms in another big Trekker bag.
I keep my (2) DSLR bodies, and (5) SLR bodies in three smaller trekker bags, and my three flashes, and other misc stuff in yet another bag. These bags and the two lens bags always stay home.
When I want to go out and shoot, I pick out one or two lenses, a body or two and place those items in a bag I use just when I'm out and about; I like to travel as light and loose as possible, keeping the majority of my kit at home.
A few mentioned spreading the kit across several parts of the house; so the wife doesn't freak at the amount of kit one has. One of the reasons I divorced my 2nd wife was because she blew a fuse every time I bought kit. Over time I did what I had to do; I left her. A week after the divorce was finalized, I blew several thousand on kit, and talk about liberation, wow!! While driving to a photo shoot, I saw her car on the freeway, and I got next to her and waved my 400mm F2.8 out the window at her....this was 100 times more insulting to her then had I gave her the bird with both hands...honest! Damnation I nearly dropped the lens on the 405 freeway, I was laughing so hard....